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NMR can provide a realistic, dynamic and/or time averaged view of a macromolecule ligand interface or, even, the transient intramolecular interfaces seen during protein folding not available by other methods. USA 108, 6121-6126 (2011) 2KXL Wittlich M, Koenig BW, Stoldt M, Schmidt H, Willbold D NMR structural characterization of HIV-1 virus protein U cytoplasmic domain in the presence of dodecylphosphatidylcholine micelles. 276, 6560-75 (2009) 2K7Y Schmidt H, Hoffmann S, Tran T, Stoldt M, Stangler T, Wiesehan K, Willbold D Solution structure of a Hck SH3 domain ligand complex reveals novel interaction modes.

This is an advantage in probing the role of local entropic contributions to binding using relaxation methods, and in the dissection of localized weak contributions, as in the 'SAR (structure activity relationships) by NMR' approach.

elucidating protein structure-27elucidating protein structure-4

The precision and accuracy of solution structures by NMR improved dramatically and the upper range of molecular weights accessible to NMR structure determination is still increasing.

Silver nanoparticles (Ag NPs) have been broadly used as antibacterial and antiviral agents.

Further, interests for green Ag NP synthesis have increased in recent years and several results for Ag NP biological synthesis have been reported using bacteria, fungi and plant extracts.

In order to find out whether drugs work you need to know how the receptors in the cell wall are organised.

An important way of doing this is to crystallise the protein, so that it can be looked at using X-rays.




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